Signaling in development 英文参考文献.docVIP

/2001/2/4/reports/4010.1 Meeting report Signaling in development David Chambers Address: MRC Centre for Developmental Neurobiology, King?s College London, Guy?s Campus, London, SE1 1UL, UK. E-mail: david.2.chambers@kcl.ac.uk Published: 4 April 2001 GenomeBiology 2001, 2(4):reports4010.1–4010.3 The electronic version of this article is the complete one and can be found online at /2001/2/4/reports/4010 ? BioMed Central Ltd (Print ISSN 1465-6906; Online ISSN 1465-6914) are expressed in the mesenchymal tissues adjacent to the A report on the ‘Integration of Signaling Pathways in Development’ Keystone Symposium, Keystone, Colorado, USA, 27 January to 1 February 2001. prospective AER of the forelimb and hindlimb, respectively, act upstream of the 7G7s, via the adhesion-associated protein -catenin, to initiate the signaling cascade required to direct limb outgrowth. Izpisua Belmonte provided prelim- inary new evidence for the role that BMPs play in this process, showing that a secreted modifier of the Wnt pathway, Dickkopf, is under control of BMP in the develop- ing limb. In addition, Alan Michelson (Harvard Medical School, Boston, USA) showed how refined such studies can be, using the specification of muscle and cardiac progenitors in Drosophila as a model system. He presented evidence indicating that mesoderm-specific expression of the progeni- tor-identity transcription factor gene even-skipped (Eve) was a direct result of combinatorial and convergent signaling from many pathways on a single small enhancer region downstream of the Eve coding region. His group has shown that this enhancer integrates information from the Ras GTPase and the Wnt and BMP pathways and from two tissue-specific transcription factors, Twist and Tinman. Thus, these studies provided good examples of how develop- mental specificity is achieved