Stem Cells for the Treatment of Neurodegenerative Diseases 英文参考文献.docVIP

Molecules 2010, 15, 6743-6758; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Stem Cells for the Treatment of Neurodegenerative Diseases Yong-Ping Wu, Wei-Shan Chen, Chong Teng and Ning Zhang * Department of Orthopaedics, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, #88 Jiefang Road, Hangzhou, 310009, China * Author to whom correspondence should be addressed; E-Mail: zhangning98@; Tel.: +86 57186021763; Fax: +86 57187022776. Received: 13 August 2010; in revised form: 6 September 2010 / Accepted: 8 September 2010 / Published: 27 September 2010 Abstract: Neurodegenerative diseases are characterized by neurodegenerative changes or apoptosis of neurons involved in networks, leading to permanent paralysis and loss of sensation below the site of the injury. Cell replacement therapy has provided the basis for the development of potentially powerful new therapeutic strategies for a broad spectrum of human neurological diseases. In recent years, neurons and glial cells have successfully been generated from stem cells, and extensive efforts by investigators to develop stem cell- based brain transplantation therapies have been carried out. We review here notable previously published experimental and preclinical studies involving stem cell-based cell for neurodegenerative diseases and discuss the future prospects for stem cell therapy of neurological disorders in the clinical setting. Steady and solid progress in stem cell research in both basic and preclinical settings should support the hope for development of stem cell-based cell therapies for neurological diseases. Keywords: stem cell; neurodegenerative diseases; treatment 1. Introduction Neurodegenerative diseases, such as Parkinson’s disease (PD), stroke, Huntington’s disease (HD) and amyotrophic lateral sclerosis (ALS), are characterized by neurodegenerative