Statins but not fibrates improve the atherogenic to anti-atherogenic lipoprotein particle ratio a randomized crossover study 英文参考文献.docVIP

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Statins but not fibrates improve the atherogenic to anti-atherogenic lipoprotein particle ratio a randomized crossover study 英文参考文献.doc

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BMC Clinical Pharmacology BioMedCentral Research article Open Access Statins but not fibrates improve the atherogenic to anti-atherogenic lipoprotein particle ratio: a randomized crossover study Sammy Y Chan*1,2, GB John Mancini1,2, Andrew Ignaszewski1,2 and Jiri Frohlich2,3 Address: 1Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, Canada, 2Healthy Heart Program, St. Pauls Hospital, Vancouver, Canada and 3Department of Laboratory Medicine, University of British Columbia, Vancouver, Canada Email: Sammy Y Chan* - syc@interchange.ubc.ca; GB John Mancini - mancini@interchange.ubc.ca; Andrew Ignaszewski - aignaszewski@providencehealth.bc.ca; Jiri Frohlich - jifr@interchange.ubc.ca * Corresponding author Published: 28 October 2008 Received: 18 March 2008 Accepted: 28 October 2008 BMC Clinical Pharmacology 2008, 8:10 doi:10.1186/1472-6904-8-10 This article is available from: /1472-6904/8/10 ? 2008 Chan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Prior studies suggested low density lipoprotein particle (LDLP) size is a predictor of atherosclerosis. Knowledge of effects of lipid lowering drugs on lipoprotein subclasses is useful. We treated subjects with hyperlipidemia sequentially with statins and fibrates, the 2 main classes of lipid lowering therapy and studied changes in NMR lipoprotein subclasses. Methods: 35 subjects (21 males; 60 ± 12 y) were enrolled in a crossover study. Subjects had baseline lipid profile apoB. Lipoprotein subclasses, particle numbers and diameters were assessed with NMR spectroscopy. Subjects were randomized to simvastatin 20 mg or fenofibrate 200 mg. Repeat testing was done at 12 weeks. After 6 week w