Streptococcus pneumoniae Serotype 3 among Costa Rican Children with Otitis Media clinical, epidemiological characteristics and antimicrobial resistance patterns 英文参考文献.docVIP

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Streptococcus pneumoniae Serotype 3 among Costa Rican Children with Otitis Media clinical, epidemiological characteristics and antimicrobial resistance patterns 英文参考文献.doc

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Streptococcus pneumoniae Serotype 3 among Costa Rican Children with Otitis Media clinical, epidemiological characteristics and antimicrobial resistance patterns 英文参考文献

BMC Pediatrics BioMedCentral Research article Open Access Streptococcus pneumoniae Serotype 3 among Costa Rican Children with Otitis Media: clinical, epidemiological characteristics and antimicrobial resistance patterns Arturo Abdelnour*1, Carolina Soley1, Silvia Guevara1, Nurith Porat3,4, Ron Dagan3,4 and Adriano Arguedas1,2 Address: 1Instituto de Atención Pediátrica, San José, Costa Rica, 2Universidad de Ciencias Médicas, San José, Costa Rica, 3Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva, Israel and 4Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer- Sheva, Israel Email: Arturo Abdelnour* - aabdelnour@; Carolina Soley - csoley@; Silvia Guevara - sguevara@; Nurith Porat - npurat@bgu.ac.il; Ron Dagan - rdagan@bgu.ac.il; Adriano Arguedas - aarguedas@bgu.ac.il * Corresponding author Published: 14 August 2009 Received: 9 February 2009 Accepted: 14 August 2009 BMC Pediatrics 2009, 9:52 doi:10.1186/1471-2431-9-52 This article is available from: /1471-2431/9/52 ? 2009 Abdelnour et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: After the introduction of the seven valent-pneumococcal conjugated vaccine into our National Immunization Program, it is important to establish and track local serotype distribution in order to evaluate its impact specially because serotype replacement phenomena has been described. To describe the clinical, epidemiological and antimicrobial resistance patterns of Costa Rican children with otitis media caused by Streptococcus pneumoniae serotype 3. Methods: Middle ear fluid samples were obtained from Costa Rican children with otitis media who participated in various antimicrobial clinical trials between