Steroidal and Phenolic Glycosides from the Bulbs of Lilium pumilum DC and Their Potential Na+K+ ATPase Inhibitory Activity 英文参考文献.docVIP

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Steroidal and Phenolic Glycosides from the Bulbs of Lilium pumilum DC and Their Potential Na+K+ ATPase Inhibitory Activity 英文参考文献.doc

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Molecules 2012, 17, 10494-10502; doi:10.3390/molecules170910494 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Steroidal and Phenolic Glycosides from the Bulbs of Lilium pumilum DC and Their Potential Na+/K+ ATPase Inhibitory Activity Zhong-Liu Zhou 1,*, Zong-Cai Feng 2, Chun-Yan Fu 3, Hua-Lin Zhang 1 and Jing-Min Xia 1 1 Chemistry Science and Technology School, Zhanjiang Normal University, 29 Cunjin Road, Zhanjiang 524048, China; E-Mails: zhanghualing303@163.com (H.L.Z.); xiajingming88@163.com (J.-M.X.) 2 Development Center for New Materials Engineering Technology in Universities of Guangdong, Zhanjiang Normal University, 29 Cunjin Road, Zhanjiang 524048, China; E-Mail: fengzongcai921@163.com 3 Department of Pharmacy, Shaoyang Medical College Level Speciaity School, 18 Baoqing Road, Shaoyang 422000, China; E-Mail: chunyanfull@ * Author to whom correspondence should be addressed; E-Mail: zlzhou@; Tel.: +86-137-2690-5138; Tel./Fax: +86-075-9318-3176. Received: 2 July 2012; in revised form: 25 August 2012 / Accepted: 29 August 2012 / Published: 3 September 2012 Abstract: A new steroidal saponin, named pumilum A (1), and a new phenolic glycoside, threo-1-(4′-hydroxy-2′-methoxyphenyl)-2-(2′′,4′′-dihydroxyphenyl)-1,3-propanediol-4′-O- β-D-glucopyranoside (7) were isolated from the methanolic extract of the bulbs of Lilium pumilum DC, along with five known steroidal saponins. Their chemical structures were elucidated on the basis of detailed spectroscopic analysis, including 1D and 2D NMR techniques and chemical methods. In addition, the inhibitory activity of all the isolates on Na+/K+ ATPase was evaluated. Keywords: Lilium pumilum DC; pumilum A; Na+/K+ ATPase 1. Introduction “Bǎi-hé”, a Chinese crude drug, is prepared from the bulbs of the Lilium species and is regularly used nowadays in China as a sedative, antitussive and anti-inflammatory agent [1–4]. Previously, Molecules 2012, 17 10495 phenol