Statistical assessment of the global regulatory role of histone acetylation in Saccharomyces cerevisiae 英文参考文献.docVIP

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Statistical assessment of the global regulatory role of histone acetylation in Saccharomyces cerevisiae 英文参考文献.doc

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Statistical assessment of the global regulatory role of histone acetylation in Saccharomyces cerevisiae 英文参考文献

Open Access Re rch 2006YuanetVoal.lumesea7, Issue 8, Article R70 Statistical assessment of the global regulatory role of histone acetylation in Saccharomyces cerevisiae ¤ ¤ Guo-Cheng Yuan *?, Ping Ma ?§, Wenxuan Zhong* and Jun S Liu* Addresses: *Department of Statistics, Harvard University, Cambridge, MA 02138, USA. ?Bauer Center for Genomics Research, Harvard University, Cambridge, MA 02138, USA. ?Department of Statistics, University of Illinois, Champaign, IL 61820, USA. §Institute for Genomic Biology, University of Illinois, Champaign, IL 61820, USA. ¤ These authors contributed equally to this work. Correspondence: Jun S Liu. Email: jliu@ Published: 2 August 2006 Received: 5 April 2006 Revised: 5 June 2006 Accepted: 2 August 2006 Genome Biology 2006, 7:R70 (doi:10.1186/gb-2006-7-8-r70) The electronic version of this article is the complete one and can be found online at /2006/7/8/R70 ? 2006 Yuan et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. HistonempodAelnfaoacetylationnr agllyosbiaslohfigsetinonoyeasteme-widecetylathistoneion./pacetylation data using a few complementary statistical models gives support to a cumulative effect Abstract Background: Histone acetylation plays important but incompletely understood roles in gene regulation. A comprehensive understanding of the regulatory role of histone acetylation is difficult because many different histone acetylation patterns exist and their effects are confounded by other factors, such as the transcription factor binding sequence motif information and nucleosome occupancy. Results: We analyzed recent genomewide histone acetylation data using a few complementary statistical models and tested the validity of a cumulative mode