Staphylococcus aureus α-Toxin Triggers the Synthesis of B-Cell Lymphoma 3 by Human Platelets 英文参考文献.docVIP
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Staphylococcus aureus α-Toxin Triggers the Synthesis of B-Cell Lymphoma 3 by Human Platelets 英文参考文献
Toxins 2011, 3, 120-133; doi:10.3390/toxins3020120
OPEN ACCESS
toxins
ISSN 2072-6651
/journal/toxins
Article
Staphylococcus aureus α-Toxin Triggers the Synthesis of B-Cell
Lymphoma 3 by Human Platelets
Sebastian Schubert 1, Hansj?rg Schwertz 2, Andrew S. Weyrich 2, Zechariah G. Franks 2,
Stephan Lindemann 3, Monika Otto 1, Hagen Behr 1, Harald Loppnow 1, Axel Schlitt 1,
Martin Russ 1, Peter Presek 4, Karl Werdan 1 and Michael Buerke 1,*
1
Department of Medicine III, Martin Luther University, Halle, Saale, Germany;
E-Mails: schubert-sebastian@ (S.S.); monika.otto@medizin.uni-halle.de (M.O.);
hagen.behr@medizin.uni-halle.de (H.B.); harald.Loppnow@medizin.uni-halle.de (H.L.);
axel.schlitt@medizin.uni-halle.de (A.S.); martin.russ@medizin.uni-halle.de (M.R.);
karl.werdan@medizin.uni-halle.de (K.W.)
2
Program in Molecular Medicine, University of Utah, Salt Lake City, UT 84112, USA;
E-Mails: hansjorg.schwertz@ (H.S.); andy.weyrich@ (A.S.W.);
zfranks@ (Z.G.F.)
3
Department of Medicine III, Eberhard Karls University, Tübingen, Germany;
E-Mail: stephan.lindemann@med.uni-tuebingen.de
4
Clinical Pharmacology, Martin Luther University, Halle, Saale, Germany;
E-Mail: peter.presek@medizin.uni-halle.de
* Author to whom correspondence should be addressed; E-Mail: michael.buerke@medizin.uni-halle.de;
Tel.: +49-345-557-2847; Fax: +49-345-557-2801.
Received: 23 December 2010; in revised form: 22 January 2011 / Accepted: 25 January 2011 /
Published: 28 January 2011
Abstract: The frequency and severity of bacteremic infections has increased over the last
decade and bacterial endovascular infections (i.e., sepsis or endocarditis) are associated
with high morbidity and mortality. Bacteria or secreted bacterial products modulate platelet
function and, as a result, affect platelet accumulation at sites of vascular infection and
inflammation. However, whether bacterial products regulate synthetic events in platelets is
not known. In the present study, we de
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