START lipidsterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors 英文参考文献.docVIP

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START lipidsterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors 英文参考文献.doc

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Open Access Re rch V2004Schricketoal.lumesea5, Issue 6, Article R41 START lipid/sterol-binding domains are amplified in plants and are predominantly associated with homeodomain transcription factors Kathrin Schrick*, Diana Nguyen*, Wojciech M Karlowski? and Klaus FX Mayer? Addresses: *Keck Graduate Institute of Applied Life Sciences, 535 Watson Drive, Claremont, CA 91711, USA. ?Munich Information Center for Protein Sequences, Institute for Bioinformatics, GSF National Research Center for Environment and Health, Ingolst?dter Landstrasse 1, 85764 Neuherberg, Germany. Correspondence: Kathrin Schrick. E-mail: Kathrin_Schrick@ Published: 27 May 2004 Received: 27 January 2004 Revised: 8 April 2004 Accepted: 30 April 2004 Genome Biology 2004, 5:R41 The electronic version of this article is the complete one and can be found online at /2004/5/6/R41 ? 2004 Schrick et al.; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the articles original URL. STARTplpanAtssaulipid/sterol-bindingnrdveayreofpprirmotaerilys fcoounndomainstadinwiintghilniparehido/mamplifiedsteeordool-mbianiinndi(nplantsHgDS)tAtrRanda-nrseclarearitpetdpredominantlyiolinpifdacttroarnss.fe/rp(associatedSTART) owithmainhomeodomains shows that thtranscriptioney are ampliffactorsied in Abstract Background: In animals, steroid hormones regulate gene expression by binding to nuclear receptors. Plants lack genes for nuclear receptors, yet genetic evidence from Arabidopsis suggests developmental roles for lipids/sterols analogous to those in animals. In contrast to nuclear receptors, the lipid/sterol-binding StAR-related lipid transfer (START) protein domains are conserved, making them candidates for involvement in both animal and plant lipid/sterol signal transduction. Results: We surveyed putati