Structures and Chemical Equilibria of Some N-Heterocycles Containing Amide Linkages 英文参考文献.docVIP

Molecules 2003, 8, 430-438 molecules ISSN 1420-3049 Structures and Chemical Equilibria of Some N-Heterocycles Containing Amide Linkages M. S. Masoud, M. Abd El Zaher Mostafa*, R. H. Ahmed and N. H. Abd El Moneim Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia, P.O. Box 426, Alexandria 21321, Egypt; Fax: (+20) 3-3911794 * Author to whom correspondence should be addressed; e-mail: dr_abdel_zaher@ Received: 3 July 2000; in revised form 12 January 2003 / Accepted: 15 April 2003 / Published: 31 May 2003 Abstract: Structures and chemical equilibria of 5-carboxy-2-thiouracil (1), 5,6-diphenyl- 3-hydroxy-1,2,4-triazine (2), 1-phenyl-3-methyl-5-pyrazolone (3) and 2-mercapto-4,6- dimethylpyrimidine hydrochloride (4) are reported. Their electronic transitions are assigned and pK values are evaluated and discussed. Keywords: Chemical equilibria, 5-carboxy-2-thiouracil, synthesis, electronic transitions and pK values. Introduction Nucleic acid and nucleic acid derivatives are multisite ligands. The interaction of these molecules with both natural and foreign metal species has stimulated great interest [1]. These biomolecules are of importance in enzyme reactions that require or act on nucleic acid constituents and the structures of nucleic acid-protein complexes [2]. There are several conformational aspects of the geometry of the nucleosides and nucleotides where the possibility that the bases will stack and hydrogen bonding interactions dominate [3,4]. Some of these compounds inhibited the replication of bacterial DNA selectively, completely and reversibly [5,6]. Some of these are used as anti-cancer agents [7].  Molecules 2003, 8 431 In our laboratory, Masoud et al. have published a series of papers that throw light on the chemistry of pyrimidine compounds and their complexes [8-17]. The aim of this paper is to study the structural chemistry and the chem