Structural brain change in Attention Deficit Hyperactivity Disorder identified by meta-analysis 英文参考文献.docVIP

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Structural brain change in Attention Deficit Hyperactivity Disorder identified by meta-analysis 英文参考文献.doc

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Structural brain change in Attention Deficit Hyperactivity Disorder identified by meta-analysis 英文参考文献

BMC Psychiatry BioMedCentral Research article Open Access Structural brain change in Attention Deficit Hyperactivity Disorder identified by meta-analysis Ian Ellison-Wright*1,3, Zo? Ellison-Wright2 and Ed Bullmore3 Address: 1Avon and Wiltshire Mental Health Partnership NHS Trust, Salisbury, UK, 2Child and Adolescent Mental Health Service, Dorset County Hospital NHS Foundation Trust, Dorchester, UK and 3Brain Mapping Unit, University of Cambridge, Cambridge, UK Email: Ian Ellison-Wright* - ian.ew@; Zo? Ellison-Wright - zoe.ellison-wright@dchft.nhs.uk; Ed Bullmore - etb23@cam.ac.uk * Corresponding author Published: 30 June 2008 Received: 7 May 2008 Accepted: 30 June 2008 BMC Psychiatry 2008, 8:51 doi:10.1186/1471-244X-8-51 This article is available from: /1471-244X/8/51 ? 2008 Ellison-Wright et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The authors sought to map gray matter changes in Attention Deficit Hyperactivity Disorder (ADHD) using a novel technique incorporating neuro-imaging and genetic meta-analysis methods. Methods: A systematic search was conducted for voxel-based structural magnetic resonance imaging studies of patients with ADHD (or with related disorders) in relation to comparison groups. The authors carried out meta-analyses of the co-ordinates of gray matter differences. For the meta-analyses they hybridised the standard method of Activation Likelihood Estimation (ALE) with the rank approach used in Genome Scan Meta-Analysis (GSMA). This system detects three- dimensional conjunctions of co-ordinates from multiple studies and permits the weighting of studies in relation to sample size. Results: For gray matter decreases, there were 7 stu