Strategy for encoding and comparison of gene expression signatures 英文参考文献.docVIP

Open Access So are 2007YietVoal.lumeftw8, Issue 7, Article R133 Strategy for encoding and comparison of gene expression signatures Yajun Yi*, Chun Li?, Clay Miller* and Alfred L George Jr*? Addresses: *Department of Medicine, Garland Avenue, Vanderbilt University, Nashville, Tennessee 37232-0275,USA. ?Department of Biostatistics, Garland Avenue, Vanderbilt University, Nashville, Tennessee 37232-0275,USA. ?Department of Pharmacology, Garland Avenue, Vanderbilt University, Nashville, Tennessee 37232-0275,USA. Correspondence: Alfred L George. Email: al.george@Vanderbilt.Edu Published: 5 July 2007 Received: 11 April 2007 Revised: 13 June 2007 Accepted: 5 July 2007 Genome Biology 2007, 8:R133 (doi:10.1186/gb-2007-8-7-r133) The electronic version of this article is the complete one and can be found online at /2007/8/7/R133 ? 2007 Yi et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ComparisonlapboEraXtoArLieTs.(ofE/Xpexpressionpression sisignaturesgnature AnaLysis Tool) enables comparisons of microarray data across experimental platforms and different Abstract EXALT (EXpression signature AnaLysis Tool) is a computational system enabling comparisons of microarray data across experimental platforms and different laboratories http:// /exalt/. An essential feature of EXALT is a database holding thousands of gene expression signatures extracted from the Gene Expression Omnibus, and encoded in a searchable format. This novel approach to performing global comparisons of shared microarray data may have enormous value when coupled directly with a shared data repository. Rationale of these data. New paradigms for searching and comparing The application of high-throughput microarray technology publicly available micr