Stratification, Blinding and Placebo Effect in a Randomized, Double Blind Placebo-controlled Clinical Trial of Gold Bead Implantation in Dogs with Hip Dysplasia 英文参考文献.docVIP

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Stratification, Blinding and Placebo Effect in a Randomized, Double Blind Placebo-controlled Clinical Trial of Gold Bead Implantation in Dogs with Hip Dysplasia 英文参考文献.doc

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Stratification, Blinding and Placebo Effect in a Randomized, Double Blind Placebo-controlled Clinical Trial of Gold Bead Implantation in Dogs with Hip Dysplasia 英文参考文献

Acta vet. scand. 2005, 46, 57-68. Strati?cation, Blinding and Placebo Effect in a Randomized, Double Blind Placebo-controlled Clinical Trial of Gold Bead Implantation in Dogs with Hip Dysplasia By G. T. J?ger1, S. Larsen2 and L. Moe3 1Department of Companion Animal Clinical Sciences, 2Department of Production Animal Clinical Sciences, 1,2,3Norwegian School of Veterinary Science, Oslo Norway. J?ger GT, Larsen S, Moe L: Strati?cation, Blinding and Placebo Effect in a Ran- domized, Double Blind Placebo-controlled Clinical Trial of Gold Bead Implanta- tion in Dogs with Hip Dysplasia. Acta vet. Scand. 2005, 46, 57-68. – The purpose of this study was to investigate the need for and choice of strati?cation factors, and the ef- fects of blinding and placebo in a clinical experiment. Eighty dogs with canine hip dys- plasia (CHD) were included in a randomized, placebo-controlled and double blind clin- ical trial with strati?ed parallel group design, in which body weight and degree of CHD were used as strati?cation factors. Thirty-eight dogs were allocated to gold bead im- plantation and 42 to placebo. After six months, 33 of the 42 placebo-treated dogs re- ceived gold bead implantation in an open study lasting a further 18 months. The main outcome variable in the study was change in pain signs of CHD as assessed by the owner. No signi?cant difference in the main outcome variable, regardless of the treat- ment given, could be detected in the two chosen strati?cation factors. The only factor to in?uence the main outcome variable signi?cantly was age. The blinding procedure used in the study, in which 60% of the owners correctly guessed the treatment given, was found suf?cient. Of those who guessed the treatment erroneously, 88% believed the treatment given was gold bead implantation. The treatment ef?cacy after six months in the blinded treatment group was found to be signi?cantly larger compared to the ef?- cacy obtained in the open stu