Synthesis and biological evaluation of propargyl acetate derivatives as anti-mycobacterial agents 英文参考文献.docVIP

Azerangetal.DARUJournalofPharmaceuticalSciences2012,20:90 /content/20/1/90 RESEARCH ARTICLE OpenAccess Synthesisandbiologicalevaluationofpropargyl acetatederivativesasanti-mycobacterialagents ParisaAzerang1,AliHosseinRezayan2,SoroushSardari1*,FarzadKobarfard3,4,MitraBayat4andKimiaTabib3 Abstract Background:Theemergenceofmultidrug-resistantstrainsofMycobacteriumtuberculosis(Mtb)hasintensified effortstodiscovernoveldrugsfortuberculosis(TB)treatment.TargetingthepersistentstateofMtb,aconditionin whichMtbisresistanttoconventionaldrugtherapies,isofparticularinterest. Methods:Thisstudyisfocusedonp