Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis 英文参考文献.docVIP
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Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis 英文参考文献
Ishidaetal.AnnalsofClinicalMicrobiologyandAntimicrobials2011,10:3
/content/10/1/3
RESEARCH
OpenAccess
Syntheticarylquinuclidinederivativesexhibit
antifungalactivityagainstCandidaalbicans,
CandidatropicalisandCandidaparapsilopsis
KellyIshida1,JulianyColaFernandesRodrigues2,SimonCammerer3,JulioAUrbina4,IanGilbert3,
WanderleydeSouza2,5,SoniaRozental1*
Abstract
Background:Sterolbiosynthesisisanessentialpathwayforfungalsurvival,andisthebiochemicaltargetofmany
antifungalagents.Theantifungaldrugsmostwidelyusedtotreatedfungalinfectionsarecompoundsthatinhibit
cytochromeP450-dependentC14a-demethylase(
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