Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks 英文参考文献.docVIP
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Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks 英文参考文献
Newmanetal.GenomeMedicine2012,4:16
/content/4/2/16
RESEARCH
OpenAccess
Systems-levelanalysisofage-relatedmacular
degenerationrevealsglobalbiomarkersand
phenotype-specificfunctionalnetworks
AaronMNewman1,5,NatashaBGallo1,LisaSHancox2,NormaJMiller3,CarolynMRadeke1,MichelleAMaloney1,
JamesBCooper4,GregorySHageman3,DonHAnderson1,LincolnVJohnson1andMonteJRadeke1*
Abstract
Background:Age-relatedmaculardegeneration(AMD)isaleadingcauseofblindnessthataffectsthecentral
regionoftheretinalpigmentedepithelium(RPE),choroid,andneuralretina.Initiallycharacterizedbyan
accumulationofsub-RPEdeposits,AMDleadsto
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