Tackling the methylome recent methodological advances in genome-wide methylation profiling 英文参考文献.docVIP

Review Tackling the methylome: recent methodological advances in genome-wide methylation profiling Marcos RH Estécio and Jean-Pierre J Issa Address: Department of Leukemia, UT MD Anderson Cancer Center, Houston, TX 77030, USA. Correspondence: Jean-Pierre J Issa. Email: jpissa@ called CpG islands. A widely accepted definition of CpG islands was formulated by Gardiner-Garner and Frommer and takes into account local GC content, observed-to- Abstract DNA methylation of promoter CpG islands is strongly associated with gene silencing and is known as a frequent cause of