TAM receptor ligands in lupus Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus 英文参考文献.docVIP

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TAM receptor ligands in lupus Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus 英文参考文献.doc

TAM receptor ligands in lupus Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus 英文参考文献

Suhetal.ArthritisResearchTherapy2010,12:R146 /content/12/4/R146 RESEARCH ARTICLE OpenAccess TAMreceptorligandsinlupus:ProteinSbutnot Gas6levelsreflectdiseaseactivityinsystemic lupuserythematosus Chang-HeeSuh1,2,BrendanHilliard1,SophiaLi1,JoanTMerrill3,PhilipLCohen1* Abstract Introduction:TheTAM(tyro3,axl,mer)kinasesarekeyregulatorsofinnateimmunityandareimportantinthe phagocytosisofapoptoticcells.Gas6andproteinSareligandsfortheseTAMkinasesandbindtophosphatidyl serineresiduesexposedduringapoptosis.Inanimalmodels,absenceofTAMkinasesisassociatedwithlupus-like disease.Totestwhetherhumansystemicl

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TAM receptor ligands in lupus Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus 英文参考文献.docVIP