Testing for rare variant associations in complex diseases 英文参考文献.docVIP

Asimit and Zeggini Genome Medicine 2011,3:24 /content/3/4/24 RESEARCH HIGHLIGHT Testing for rare variant associations in complex diseases Jennifer Asimit* and Eleftheria Zeggini by Asimit and Zeggini [5]), but many of them experience Abstract a large drop in power when both protective and risk The study of rare variants holds the promise of accounting for some of the missing heritability in complex traits. Next-generation sequencing technologies enable probing of variation across the full spectrum of allele frequencies. Multiple methods for the analysis of rare variants hav