原创力文档The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes 英文参考文献.docVIP
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GranandCameron-SmithBMCPhysiology2011,11:10
/1472-6793/11/10
RESEARCH ARTICLE
OpenAccess
TheactionsofexogenousleucineonmTOR
signallingandaminoacidtransportersin
humanmyotubes
PetraGranandDavidCameron-Smith*
Abstract
Background:Thebranched-chainaminoacid(BCAA)leucinehasbeenidentifiedtobeakeyregulatorofskeletal
muscleanabolism.Activationofanabolicsignallingoccursviathemammaliantargetofrapamycin(mTOR)through
anundefinedmechanism.SystemAandLsolutecarrierstransportessentialaminoacidsacrossplasma
membranes;howeveritremainsunknownwhetheranexogenoussupplyofleucineregulatestheirgene
expression.Theai
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