The Changing Microbial Environment and Chronic Inflammatory Disorders 英文参考文献.docVIP

ORIGINAL ARTICLE TheChangingMicrobialEnvironmentandChronic InflammatoryDisorders GrahamA.W.Rook,BA,MB,BChir,MD There is much to be gained from examining human diseases within the expanding framework of Darwinian medicine. This is particularlytrueofthoseconditionsthatchangeinfrequencyaspopulationsdevelopfromthehuman‘‘environmentofevolutionary adaptedness’’tothelivingconditionsoftherichindustrializedcountries.Thisdevelopmententailsmajorchangesinlifestyle,leading to reductions in contact with environmental microorganisms and helminths that have evolved a physiologic role as drivers of immunoreg