The Difficult-to-Control Asthmatic A Systematic Approach 英文参考文献.docVIP

Review Article The Difficult-to-Control Asthmatic: A Systematic Approach Annie V. Le, MD; Ronald A. Simon, MD Abstract With the judicious use of inhaled corticosteroids,? agonists, and leukotriene modifiers, most patients 2 with asthma are easily controlled and managed. However, approximately 5% of asthmatics do not respond to standard therapy and are classified as “difficult to control.” Typically, these are patients who 1 complain of symptoms interfering with daily living despite long-term treatment with inhaled corticosteroids in doses up to 2,000?g daily. Many factors can co