原创力文档The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells 英文参考文献.docVIP
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Hiyamaetal.ArthritisResearchTherapy2012,14:R105
/content/14/3/R105
RESEARCH ARTICLE
OpenAccess
Theeffectsofoxygentensionandantiaging
factorKlothoonWntsignalinginnucleus
pulposuscells
AkihikoHiyama1,2*,FumiyukiArai1,2,DaisukeSakai1,2,KatsuyaYokoyama1,2 andJojiMochida1,2
Abstract
Introduction:ThegoalsofthisstudyweretoexaminetheoxemicregulationofWntsignalingtoexplorewhether
Wntsignalingacceleratestheage-relateddegenerationofnucleuspulposuscells,andifso,todefinethe
mechanismunderlyingthiseffect.WeinvestigatedtheexpressionofKlotho,anewlyidentifiedantiaginggene,and
whetheritsregulationisattri
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