The influence of genomics and proteomics on the development of potential vaccines against meningococcal infection 英文参考文献.docVIP

Heckels and Williams Genome Medicine 2010,2:43 /content/2/7/43 REVIEW The in?uence of genomics and proteomics on the development of potential vaccines against meningococcal infection John E Heckels* and Jeannette N Williams ? ? e ?rst generation of vaccines contained puri?ed polysaccharides from serogroups A and C that induced antibodies that promoted complement-mediated serum bactericidal activity (SBA), the correlate of protective immunity, against the respective serogroups. Tetravalent pol