The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir is there a clinical advantage 英文参考文献.docVIP
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The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir is there a clinical advantage 英文参考文献
Wiesmannetal.AIDSResearchandTherapy2011,8:7
/content/8/1/7
SHORT REPORT
OpenAccess
TheL76VmutationinHIV-1proteaseispotentially
associatedwithhypersusceptibilitytoprotease
inhibitorsAtazanavirandSaquinavir:istherea
clinicaladvantage?
FrankWiesmann1*,JanVachta1,RobertEhret1,HaukeWalter2,RolfKaiser3,MartinStürmer4,AndréTappe5,
MartinD?umer6,ThomasBerg7,GudrunNaeth1,PatrickBraun1,HeribertKnechten1
Abstract
Background:AlthoughbeingconsideredasararelyobservedHIV-1proteasemutationinclinicalisolates,the
L76V-prevalenceincreased1998-2008insomeEuropeancountriesmostlikelyduetotheapprovalofLopinavir,
Am
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