The mastermind approach to CNS drug therapy translational prediction of human brain distribution, target site kinetics, and therapeutic effects 英文参考文献.docVIP

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The mastermind approach to CNS drug therapy translational prediction of human brain distribution, target site kinetics, and therapeutic effects 英文参考文献.doc

The mastermind approach to CNS drug therapy translational prediction of human brain distribution, target site kinetics, and therapeutic effects 英文参考文献

deLangeFluidsandBarriersoftheCNS2013,10:12 /content/10/1/12 FLUIDS AND BARRIERS OF THE CNS REVIEW OpenAccess ThemastermindapproachtoCNSdrugtherapy: translationalpredictionofhumanbrain distribution,targetsitekinetics,andtherapeutic effects ElizabethCMdeLange Abstract DespiteenormousadvancesinCNSresearch,CNSdisordersremaintheworld’sleadingcauseofdisability.This accountsformorehospitalizationsandprolongedcarethanalmostallotherdiseasescombined,andindicatesa highunmetneedforgoodCNSdrugsanddrugtherapies. Followingdosing,notonlythechemicalpropertiesofthedrugandblood–brainbarrier(BBB)transport,butal

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The mastermind approach to CNS drug therapy translational prediction of human brain distribution, target site kinetics, and therapeutic effects 英文参考文献.docVIP