The Use of Antiepileptic Drugs (AEDs) for the Treatment of Pediatric Aggression and Mood Disorders 英文参考文献.docVIP

Pharmaceuticals 2010, 3, 2986-3004; doi:10.3390/ph3092986 OPEN ACCESS pharmaceuticals ISSN 1424-8247 /journal/pharmaceuticals Review The Use of Antiepileptic Drugs (AEDs) for the Treatment of Pediatric Aggression and Mood Disorders Kaizad R. Munshi 1,*, Tanya Oken 1, Danielle J. Guild 1, Harsh K. Trivedi 2, Betty C. Wang 3, Peter Ducharme 1 and Joseph Gonzalez-Heydrich 1 1 Department of Psychiatry, Children’s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA 2 Vanderbilt Psychiatric Hospital, Vanderbilt University School of Medicine, 1601 23rd Avenue South, Room 1157, Nashville, TN 37212, USA 3 Massachusetts General Hospital, Simches Research Building, Harvard Medical School, 185 Cambridge Street, 2nd Floor, Boston, MA 02114, USA * Author to whom correspondence should be addressed; E-Mail: kaizad.munshi@. Received: 5 August 2010; in revised form: 31 August 2010 / Accepted: 3 September 2010 / Published: 10 September 2010 Abstract: Aggressive symptomatology presents across multiple psychiatric, developmental, neurological and behavioral disorders, complicating the diagnosis and treatment of the underlying pathology. Anti-Epileptic Drugs (AEDs) have become an appealing alternative in the treatment of aggression, mood lability and impulsivity in adult and pediatric populations, although few controlled trials have explored their efficacy in treating pediatric populations. This review of the literature synthesizes the available data on ten AEDs—valproate, carbamazepine, oxcarbazepine, phenytoin, lamotrigine, topiramate, levetiracetam, zonisamide, gabapentin and tiagabine—in an attempt to assess evidence for the efficacy of AEDs in the treatment of aggression in pediatric populations. Our review revealed modest evidence that some of the AEDs produced improvement in pediatric aggression, but controlled trials in pediatric bipolar disorder have not been promi