The Use of Antiepileptic Drugs (AEDs) for the Treatment of Pediatric Aggression and Mood Disorders 英文参考文献.docVIP
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The Use of Antiepileptic Drugs (AEDs) for the Treatment of Pediatric Aggression and Mood Disorders 英文参考文献
Pharmaceuticals 2010, 3, 2986-3004; doi:10.3390/ph3092986
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
The Use of Antiepileptic Drugs (AEDs) for the Treatment of
Pediatric Aggression and Mood Disorders
Kaizad R. Munshi 1,*, Tanya Oken 1, Danielle J. Guild 1, Harsh K. Trivedi 2, Betty C. Wang 3,
Peter Ducharme 1 and Joseph Gonzalez-Heydrich 1
1
Department of Psychiatry, Children’s Hospital Boston, Harvard Medical School, 300 Longwood
Avenue, Boston, MA 02115, USA
2
Vanderbilt Psychiatric Hospital, Vanderbilt University School of Medicine, 1601 23rd Avenue
South, Room 1157, Nashville, TN 37212, USA
3
Massachusetts General Hospital, Simches Research Building, Harvard Medical School, 185
Cambridge Street, 2nd Floor, Boston, MA 02114, USA
* Author to whom correspondence should be addressed;
E-Mail: kaizad.munshi@.
Received: 5 August 2010; in revised form: 31 August 2010 / Accepted: 3 September 2010 /
Published: 10 September 2010
Abstract:
Aggressive
symptomatology
presents
across
multiple
psychiatric,
developmental, neurological and behavioral disorders, complicating the diagnosis and
treatment of the underlying pathology. Anti-Epileptic Drugs (AEDs) have become an
appealing alternative in the treatment of aggression, mood lability and impulsivity in adult
and pediatric populations, although few controlled trials have explored their efficacy in
treating pediatric populations. This review of the literature synthesizes the available data
on ten AEDs—valproate, carbamazepine, oxcarbazepine, phenytoin, lamotrigine,
topiramate, levetiracetam, zonisamide, gabapentin and tiagabine—in an attempt to assess
evidence for the efficacy of AEDs in the treatment of aggression in pediatric populations.
Our review revealed modest evidence that some of the AEDs produced improvement in
pediatric aggression, but controlled trials in pediatric bipolar disorder have not been
promi
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