The Use of Response Surface Methodology to Optimize the Ultrasound-Assisted Extraction of Five Anthraquinones from Rheum palmatum L. 英文参考文献.docVIP

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The Use of Response Surface Methodology to Optimize the Ultrasound-Assisted Extraction of Five Anthraquinones from Rheum palmatum L. 英文参考文献.doc

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The Use of Response Surface Methodology to Optimize the Ultrasound-Assisted Extraction of Five Anthraquinones from Rheum palmatum L. 英文参考文献

Molecules 2011, 16, 5928-5937; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article The Use of Response Surface Methodology to Optimize the Ultrasound-Assisted Extraction of Five Anthraquinones from Rheum palmatum L. Li-Chun Zhao 1,2, Jian Liang 2,*, Wei Li 3, Kun-Mu Cheng 4, Xianghua Xia 1, Xin Deng 2 and Geng-Liang Yang 1,* 1 College of Pharmacy, Hebei University, Baoding 071002, China 2 The Affiliated Ruikang Hospital of Guangxi Traditional Chinese Medical College, Nanning 530011, China; E-Mail: hyzlc@126.com (L.-C.Z.) 3 College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China 4 Department of Chemistry and Chemical Engineering, Ankang University, Ankang 725000, China * Authors to whom correspondence should be addressed; E-Mails: hbyanggl@126.com (G.-L.Y.); ljruikang@126.com (J.L.); Tel.: +86-771-2188589; Fax: +86-771-2335098. Received: 1 June 2011; in revised form: 7 July 2011 / Accepted: 11 July 2011 / Published: 15 July 2011 Abstract: In this paper, ultrasound-assisted extraction (UAE) was applied to the extraction of anthraquinones (aloe-emodin, rhein, emodin, chrysophanol and physcion) from Rheum palmatum L. The five anthraquinones were quantified and analyzed by high performance liquid chromatography coupled with UV detection (HPLC-UV). The extraction solvent, extraction temperature and extraction time parameters, the three main factors for UAE, were optimized with response surface methodology (RSM) to obtain the highest extraction efficiency. The optimal conditions were the use of 84% methanol as solvent, an extraction time of 33 min and an extraction temperature of 67 °C. Under these optimal conditions, the experimental values agreed closely with the predicted values. The analysis of variance indicated a high goodness of model fit and the success of RSM method for optimizing anthraquinones extraction in Rheum palmatum L. Key