Theoretical Analysis of the Performance of Glucose Sensors with Layer-by-Layer Assembled Outer Membranes 英文参考文献.docVIP

Sensors 2012, 12, 13402-13416; doi:10.3390/s121013402 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Article Theoretical Analysis of the Performance of Glucose Sensors with Layer-by-Layer Assembled Outer Membranes Robert A. Croce Jr. 1, Santhisagar Vaddiraju 2,3, Fotios Papadimitrakopoulos 3,4 and Faquir C. Jain 1,* 1 Electrical and Computer Engineering, University of Connecticut, 371 Fairfield Way, Storrs, CT 06269, USA; E-Mail: rjc03001@ 2 Biorasis Inc., Technology Incubation Program, University of Connecticut, Storrs, CT 06269, USA 3 Nanomaterials Optoelectronics Laboratory, Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA; E-Mails: sagar@ (S.V.); papadim@ (F.P.) 4 Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA * Author to whom correspondence should be addressed; E-Mail: fcj@; Tel.: +1-860-486-3752; Fax: +1-860-486-2447. Received: 22 August 2012; in revised form: 25 September 2012 / Accepted: 28 September 2012 / Published: 1 October 2012 Abstract: The performance of implantable electrochemical glucose sensors is highly dependent on the flux-limiting (glucose, H2O2, O2) properties of their outer membranes. A careful understanding of the diffusion profiles of the participating species throughout the sensor architecture (enzyme and membrane layer) plays a crucial role in designing a robust sensor for both in vitro and in vivo operation. This paper reports the results from the mathematical modeling of Clark’s first generation amperometric glucose sensor coated with layer-by-layer assembled outer membranes in order to obtain and compare the diffusion profiles of various participating species and their effect on sensor performance. Devices coated with highly glucose permeable (HAs/Fe3+) membranes were compared with devices coated with PSS/PDDA membranes, which have an order of magnitude lower permeability. The simulat