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The use of enoxaparin during coronary angioplasty study of clinical security 英文参考文献
Available online /supplements/7/S3
Critical Care Volume 7 Suppl 3, 2003
Second International Symposium on Intensive Care and
Emergency Medicine for Latin America
S?o Paulo, Brazil, 25–28 June 2003
Published online: 25 June 2003
These abstracts are online at /supplements/7/S3
? 2003 BioMed Central Ltd (Print ISSN 1364-8535; Online ISSN 1466-609X)
CARDIOLOGY
P1
Impact of peroperative administration of steroid over inflammatory response and pulmonary dysfunction following cardiac
surgery
HTF Mendon?a Filho1,2, LAA Campos1, RV Gomes1, FES Fagundes1, EM Nunes1, R Gomes2, F Bozza2, PT Bozza2,
HC Castro-Faria-Neto2
1Surgical Intensive Care Unit, Hospital Pró-Cardíaco, Rio de Janeiro, RJ, Brazil;
2Laboratory of Immunopharmacology, Department of Pharmacodymamics, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil
Critical Care 2003, 7(Suppl 3):P1 (DOI 10.1186/cc2197)
Introduction Cardiac surgery with cardiopulmonary bypass (CPB)
is a recognized trigger of systemic inflammatory response, usually
related to postoperative acute lung injury (ALI). As an attempt to
dampen inflammatory response, steroids have been perioperatively
administered to patients. Macrophage migration inhibitory factor
(MIF), a regulator of the endotoxin receptor, is implicated in the
pathogenesis of ALI. We have previously detected peak circulating
levels of MIF, 6 hours post CPB. Experimental data have shown
that steroids may induce MIF secretion by mononuclear cells. This
study aims to correlate levels of MIF assayed 6 hours post CPB to
the intensity of postoperative pulmonary dysfunction, analysing the
impact of perioperative steroid administration.
NS (n=37). MIF circulating levels were assayed at the anesthesia
induction, 3, 6, and 24hours after CPB. A standard weaning proto-
col with fast track strategy was adopted, and indicators of organ
dysfunction and therapeutic intervention were registered during the
first 72hours postoperative.
Results Levels of MIF
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