Thermal modeling of lesion growth with radiofrequency ablation devices 英文参考文献.docVIP

BioMedical Engineering OnLine BioMedCentral Research Open Access Thermal modeling of lesion growth with radiofrequency ablation devices Isaac A Chang*1 and Uyen D Nguyen2 Address: 1Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, Maryland, USA and 2Department of Biomedical Engineering, Catholic University of America, Washington DC, USA Email: Isaac A Chang* - IAC@CDRH.FDA.GOV; Uyen D Nguyen - nguyenu@ * Corresponding author Published: 06 August 2004 Received: 26 April 2004 Accepted: 06 August 2004 BioMedical Engineering OnLine 2004, 3:27 doi:10.1186/1475-925X-3-27 This article is available from: /content/3/1/27 ? 2004 Chang and Nguyen; licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Temperature is a frequently used parameter to describe the predicted size of lesions computed by computational models. In many cases, however, temperature correlates poorly with lesion size. Although many studies have been conducted to characterize the relationship between time-temperature exposure of tissue heating to cell damage, to date these relationships have not been employed in a finite element model. Methods: We present an axisymmetric two-dimensional finite element model that calculates cell damage in tissues and compare lesion sizes using common tissue damage and iso-temperature contour definitions. The model accounts for both temperature-dependent changes in the electrical conductivity of tissue as well as tissue damage-dependent changes in local tissue perfusion. The data is validated using excised porcine liver tissues. Results: The data demonstrate the size of the