Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits 英文参考文献.docVIP

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Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits 英文参考文献.doc

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Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits 英文参考文献

Available online /content/10/6/R133 Research article Open Access Vol 10 No 6 Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits Toshiyuki Okura1, Kousuke Marutsuka2, Hiroaki Hamada1, Tomohisa Sekimoto1, Tsuyoshi Fukushima3, Yujiro Asada2, Kazuo Kitamura4 and Etsuo Chosa1 1Division of Orthopedic Surgery, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan 2Section of Pathophysiology, Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan 3Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan 4Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan Corresponding author: Etsuo Chosa, chosa@med.miyazaki-u.ac.jp Received: 12 Jun 2008 Revisions requested: 17 Jul 2008 Revisions received: 15 Oct 2008 Accepted: 13 Nov 2008 Published: 13 Nov 2008 Arthritis Research Therapy 2008, 10:R133 (doi:10.1186/ar2550) This article is online at: /content/10/6/R133 ? 2008 Okura et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Adrenomedullin is a potent vasodilatory and mRNA levels in the synovial tissue were measured using real- time quantitative PCR. hypotensive peptide as well as an endogenous immunomodulatory factor with predominantly anti-inflammatory effects. The purpose of the present study was to evaluate the therapeutic effects of adrenomedullin in rabbits wi