Therapeutic effects of antibodies to tumor necrosis factor-α, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis 英文参考文献.docVIP

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Therapeutic effects of antibodies to tumor necrosis factor-α, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis 英文参考文献.doc

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Therapeutic effects of antibodies to tumor necrosis factor-α, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis 英文参考文献

Available online /content/10/3/R66 Research article Open Access Vol 10 No 3 Therapeutic effects of antibodies to tumor necrosis factor-α, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis Isao Matsumoto1,2, Hua Zhang1,2, Takanori Yasukochi1,2, Keiichi Iwanami1, Yoko Tanaka1, Asuka Inoue1, Daisuke Goto1, Satoshi Ito1, Akito Tsutsumi1 and Takayuki Sumida1 1Division of Clinical Immunology, Major of Advanced Biomedical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tennodai, Tsukuba 305-8575, Japan 2PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan Corresponding author: Isao Matsumoto, ismatsu@md.tsukuba.ac.jp Received: 16 Jan 2008 Revisions requested: 13 Feb 2008 Revisions received: 2 May 2008 Accepted: 5 Jun 2008 Published: 5 Jun 2008 Arthritis Research Therapy 2008, 10:R66 (doi:10.1186/ar2437) This article is online at: /content/10/3/R66 ? 2008 Matsumoto et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited Abstract Introduction Immunization with glucose-6-phosphate Results Large amounts of TNF-α and IFN-γ and small amounts isomerase (GPI) induces severe arthritis in DBA/1 mice. The present study was designed to identify the cytokines and co- stimulatory molecules involved in the development of GPI- induced arthritis. of IL-2 and IL-6 were produced by splenocytes from mice with GPI-induced arthritis. Anti-TNF-α mAbs and CTLA-4Ig suppressed TNF-α production, whereas anti-IFN-γ mAbs, anti- IL-12 mAbs, and CTLA-4 Ig inhibited IFN-γ production. A single injection of anti-TNF-α and anti-IL-6 mAbs and two injections of CTLA-4Ig reduced the severity of ar