The utility of the mannitol challenge in the assessment of chronic cough a pilot study 英文参考文献.docVIP

Cough BioMedCentral Short report Open Access The utility of the mannitol challenge in the assessment of chronic cough: a pilot study Amisha Singapuri, Susan McKenna and Christopher E Brightling* Address: Institute of Lung Health, University of Leicester, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK Email: Amisha Singapuri - a_singapuri@; Susan McKenna - sue.mckenna1@; Christopher E Brightling* - ceb17@le.ac.uk * Corresponding author Published: 18 November 2008 Received: 25 September 2008 Accepted: 18 November 2008 Cough 2008, 4:10 doi:10.1186/1745-9974-4-10 This article is available from: /content/4/1/10 ? 2008 Singapuri et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract There is a need for more objective outcome measures for chronic cough. In this pilot study we sought to investigate the utility of the mannitol challenge as a cough-provocation test in non- asthmatic chronic cough. We studied 16 healthy controls and 13 subjects with chronic cough. We assessed cough severity using a visual analogue score, capsaicin cough sensitivity, health status using the Leicester Cough Questionnaire and the dose of mannitol to cause 2 (C2) or 5 (C5) coughs. In all of the subjects with chronic cough and 6 of the controls we assessed the 1-week repeatability of the mannitol challenge. We found that in those subjects with chronic cough the geometric mean (logSEM) mannitol C2 and C5 was heightened compared to controls (C2: 4 (0.2) versus 16 (0.1); p = 0.04 and C5: 63 (0.1) versus 251 (0.1); p = 0.04). Cough visual analogue score, capsacin-induced cough sensitivity and health status were also altered in chronic cough compared to healthy controls, but in those subjects with chronic