Three New Cembranoids from the Taiwanese Soft Coral Sarcophyton ehrenbergi 英文参考文献.docVIP

Mar. Drugs 2012, 10, 1433-1444; doi:10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Three New Cembranoids from the Taiwanese Soft Coral Sarcophyton ehrenbergi Shang-Kwei Wang 1,2, Mu-Keng Hsieh 3 and Chang-Yih Duh 1,3,* 1 Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan; E-Mail: skwang@.tw 2 Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan 3 Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan; E-Mail: m995020015@.tw * Author to whom correspondence should be addressed; E-Mail: yihduh@.tw; Tel.: +886-7-525-2000 (ext. 5036); Fax: +886-7-525-5020. Received: 20 May 2012; in revised form: 10 June 2012 / Accepted: 16 June 2012 / Published: 27 June 2012 Abstract: In order to search for new bioactive substances from marine organisms, we have investigated the acetone extracts of the soft coral Sarcophyton ehrenbergi collected at San-Hsian-Tai, Taitong County, Taiwan. Chromatographic fractionation of the extracts of the octocoral S. ehrenbergi led to the isolation of three new cembranoids, (+)-12-ethoxycarbonyl-11Z-sarcophine (1), ehrenbergol A and B ( 2 and 3). The structures of these isolated metabolites were elucidated through extensive spectroscopic analyses. Moreover, metabolites 1–3 were evaluated in vitro for their cytotoxicity towards selected cancer cell lines and antiviral activity against human cytomegalovirus (HCMV). Keywords: Sarcophyton ehrenbergi; cembranoids; cytotoxicity; anti-HCMV 1. Introduction Marine organisms, which have developed unique metabolic and physiological capabilities to ensure survival in extreme ocean habitats, offer the potential to produce new bioactive constituents that would not be observed from terrestrial organisms [1]. Soft corals belonging to the genus Sarcophyton (Alcyoniid