Tight perioperative glucose control is associated with a reduction in renal impairment and renal failure in non-diabetic cardiac surgical patients 英文参考文献.docVIP

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Tight perioperative glucose control is associated with a reduction in renal impairment and renal failure in non-diabetic cardiac surgical patients 英文参考文献.doc

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Tight perioperative glucose control is associated with a reduction in renal impairment and renal failure in non-diabetic cardiac surgical patients 英文参考文献

Available online /content/12/6/R154 Research Open Access Vol 12 No 6 Tight perioperative glucose control is associated with a reduction in renal impairment and renal failure in non-diabetic cardiac surgical patients Patrick Lecomte1, Bruno Van Vlem2, Jose Coddens1, Guy Cammu1, Guy Nollet1, Frank Nobels3, Hugo Vanermen4 and Luc Foubert1 1Department of Anaesthesiology and Critical Care Medicine, Onze-Lieve-Vrouw Hospital, Moorselbaan 164, 9300 Aalst, Belgium 2Department of Nephrology, Onze-Lieve-Vrouw Hospital, Moorselbaan 164, 9300 Aalst, Belgium 3Department of Endocrinology, Onze-Lieve-Vrouw Hospital, Moorselbaan 164, 9300 Aalst, Belgium 4Department of Cardiothoracic and Vascular Surgery, Onze-Lieve-Vrouw Hospital, Moorselbaan 164, 9300 Aalst, Belgium Corresponding author: Luc Foubert, Luc.Foubert@olvz-aalst.be Received: 18 Aug 2008 Revisions requested: 20 Sep 2008 Revisions received: 4 Nov 2008 Accepted: 4 Dec 2008 Published: 4 Dec 2008 Critical Care 2008, 12:R154 (doi:10.1186/cc7145) This article is online at: /content/12/6/R154 ? 2008 Lecomte et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Acute renal failure after cardiac surgery increases in-hospital mortality. We evaluated the effect of intra- and postoperative tight control of blood glucose levels on renal function after cardiac surgery based on the Risk, Injury, Failure, Loss, and End-stage kidney failure (RIFLE) criteria, and on the need for acute postoperative dialysis. cardiopulmonary bypass onwards until ICU discharge (p 0.0001). Median ICU stay was 2 days in both groups. In non- diabetics, strict perioperative blood glucose control was associated with a reduced incidence of renal impairment (p =