Thirteen New Xanthone Derivatives from Calophyllum caledonicum (Clusiaceae) 英文参考文献.docVIP

Molecules 2002, 7, 38-50 molecules ISSN 1420-3049 Thirteen New Xanthone Derivatives from Calophyllum caledonicum (Clusiaceae) Cécile Morel1, Anne-Emmanuelle Hay1, Marc Litaudon2, Thierry Sévenet2, Denis Séraphin1, Jean Bruneton1 and Pascal Richomme1,* 1 SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la santé, 16 Bd Daviers, F-49100 Angers, France. 2 ICSN-CNRS, Gif-sur-Yvette, F-91191, France. *Author to whom correspondence should be addressed; e-mail: richomme@pharma.univ-angers.fr Received: 11 October 2001; in revised form 28 November 2001 / Accepted: 28 November 2001 / Published: 31 January 2002 Abstract: An EtOAc extract of the stem bark of Calophyllum caledonicum (Clusiaceae) yielded thirteen new hydroxylated and/or prenylated xanthone derivatives, namely 5- hydroxy-8-methoxyxanthone (1), 3,5-dihydroxy-1,2-dimethoxyxanthone (2), 1,8-dihydroxy- 6,7-dimethoxyxanthone (3), 5,7-dihydroxy-2,6-dimethoxyxanthone (4), 6,8-dihydroxy-3,7- dimethoxy-xanthone (5), 2,5,6,7,8-pentahydroxyxanthone (6), 1,3,8-trihydroxy-5,7- dimethoxyxanthone (7) and according to a previously adopted nomenclature [3], caledonixanthone G-L. (8-13). The structural elucidation of 1-13 were mainly established on the basis of 1D and 2D NMR and HRMS spectroscopic analysis. Key words: NMR, MS, xanthones, Calophyllum caledonicum, Guttiferae Introduction The genus Calophyllum (Guttiferae) is already known as a rich source of oxygenated and prenylated polyphenol derivatives belonging to the coumarin or the xanthone types of secondary metabolites [1-5]. Among 187 known species, Calophyllum caledonicum Vieill. is an endemic one restricted to  Molecules 2002, 7 39 New-Caledonia where it is locally used by natives as a diuretic. We have already shown the presence of numerous xanthones in C. caledonicum [3-5], some of them exhibiting quite interesting antifungal activities [4]. In our contin