Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+ regulatory T cells in MRLlpr mice 英文参考文献.docVIP

Available online /content/9/1/R15 Research article Open Access Vol 9 No 1 Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+ regulatory T cells in MRL/lpr mice Hitoshi Hasegawa1, Atsushi Inoue1, Masatake Muraoka1, Jun Yamanouchi1, Tatsuhiko Miyazaki2 and Masaki Yasukawa1 1First Department of Internal Medicine, Division of Pathogenomics, Ehime University School of Medicine, Shitsukawa 454, Toon City, Ehime 791- 0295, Japan 2Department of Pathology, Division of Pathogenomics, Ehime University School of Medicine, Shitsukawa 454, Toon City, Ehime 791-0295, Japan Corresponding author: Hitoshi Hasegawa, hitoshih@m.ehime-u.ac.jp Received: 25 Sep 2006 Revisions requested: 12 Oct 2006 Revisions received: 9 Jan 2007 Accepted: 7 Feb 2007 Published: 7 Feb 2007 Arthritis Research Therapy 2007, 9:R15 (doi:10.1186/ar2122) This article is online at: /content/9/1/R15 ? 2007 Hasegawa et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Adoptive transfer of CD4+CD25+ regulatory T cells has been mice and increased age-dependently. The level of CCR2 expression and MCP-1 chemotactic activity of CCR2-Treg cells were much higher than those of Treg cells. MRL/lpr mice to shown to have therapeutic effects in animal models of autoimmune diseases. Chemokines play an important role in the development of autoimmune diseases in animal models and humans. The present study was performed to investigate which CCR2-Treg cells had been transferred showed reduced progression of pneumonitis and significantly whether diseases could be reduced more markedly by accumulating chemokine receptor-expressing CD4+CD25+ regulatory T cells efficiently i