The ventro-medial prefrontal cortex a major link between the autonomic nervous system, regulation of emotion, and stress reactivity 英文参考文献.docVIP

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The ventro-medial prefrontal cortex a major link between the autonomic nervous system, regulation of emotion, and stress reactivity 英文参考文献.doc

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The ventro-medial prefrontal cortex a major link between the autonomic nervous system, regulation of emotion, and stress reactivity 英文参考文献

BioPsychoSocial Medicine BioMedCentral Review Open Access The ventro-medial prefrontal cortex: a major link between the autonomic nervous system, regulation of emotion, and stress reactivity? Alexander H?nsel* and Roland von K?nel Address: Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital Berne, Berne, Switzerland Email: Alexander H?nsel* - alexander.haensel@insel.ch; Roland von K?nel - roland.vonkaenel@insel.ch * Corresponding author Published: 5 November 2008 Received: 11 June 2008 Accepted: 5 November 2008 BioPsychoSocial Medicine 2008, 2:21 doi:10.1186/1751-0759-2-21 This article is available from: /content/2/1/21 ? 2008 Haensel and von Kaenel; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Recent progress in neuroscience revealed diverse regions of the CNS which moderate autonomic and affective responses. The ventro-medial prefrontal cortex (vmPFC) plays a key role in these regulations. There is evidence that vmPFC activity is associated with cardiovascular changes during a motor task that are mediated by parasympathetic activity. Moreover, vmPFC activity makes important contributions to regulations of affective and stressful situations. This review selectively summarizes literature in which vmPFC activation was studied in healthy subjects as well as in patients with affective disorders. The reviewed literature suggests that vmPFC activity plays a pivotal role in biopsychosocial processes of disease. Activity in the vmPFC might link affective disorders, stressful environmental conditions, and immune function. Introduction bances in autonomic nervous system activity measured by heart rate variability [6]. Moreover, other mental disorder