Towards Recyclable NAD(P)H Regeneration Catalysts 英文参考文献.docVIP

Molecules 2012, 17, 9835-9841; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication Towards Recyclable NAD(P)H Regeneration Catalysts Miriam de Torres 1,?, Jonas Dimroth 2,?, Isabel W. C. E. Arends 3, Juliane Keilitz 4,# and Frank Hollmann 3,* 1 Departamento de Química Orgánica, Universidad de Zaragoza, Pedro Cerbuna 12, E-50009, Spain 2 Department of Chemistry, Technische Universi?t Berlin, Stra?e des 17, Juni 124, Berlin 10623, Germany 3 Department of Biotechnology, Delft University of Technology, Julianalaan 136, Delft 2628BL, The Netherlands; E-Mail: i.w.c.e.arends@tudelft.nl 4 Freie Universit?t Berlin, Institute of Chemistry and Biochemistry, Takustra?e 3, Berlin 14195, Germany ? Current address: Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen 6525 AJ, The Netherlands; E-Mail: mtorres@science.ru.nl. ? Current address: Molecular Design Institute and Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA; E-Mail: jonas.dimroth@. # Current address: Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada; E-Mail: jkeilitz@chem.utoronto.ca. * Author to whom correspondence should be addressed; E-Mail: f.hollmann@tudelft.nl; Tel.: +31-15-278-1957; Fax: +31-15-278-1415. Received: 14 June 2012; in revised form: 1 August 2012 / Accepted: 8 August 2012 / Published: 15 August 2012 Abstract: Rh(III)-TsDPEN, an immobilized analog of the well-known [Cp*Rh(bpy)(H2O)]2+ was evaluated as a heterogeneous, recyclable regeneration catalyst for reduced oxidoreductase cofactors [NAD(P)H]. Repeated use of this catalyst was established and the catalytic properties were initially investigated. Apparently, Rh(III)-TsDPEN is prone to severe diffusion limitations, necessitating further developments. Overall, a promising concept for chemoenzymatic redox catalysis is