Total cholesterol and triglycerides are associated with the development of new bone marrow lesions in asymptomatic middle-aged women - a prospective cohort study 英文参考文献.docVIP

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Total cholesterol and triglycerides are associated with the development of new bone marrow lesions in asymptomatic middle-aged women - a prospective cohort study 英文参考文献.doc

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Total cholesterol and triglycerides are associated with the development of new bone marrow lesions in asymptomatic middle-aged women - a prospective cohort study 英文参考文献

Available online /content/11/6/R181 Research article Open Access Vol 11 No 6 Total cholesterol and triglycerides are associated with the development of new bone marrow lesions in asymptomatic middle-aged women - a prospective cohort study Miranda L Davies-Tuck1, Fahad Hanna1,2,3, Susan R Davis3, Robin J Bell1, Sonia L Davison3, Anita E Wluka1,2, Jenny Adams3 and Flavia M Cicuttini1 1Department of Epidemiology and Preventive Medicine, Monash University Medical School, Alfred Hospital, 89 Commercial Road, Prahran, Victoria 3004, Australia 2Baker Heart Research Institute, Commercial Road, Melbourne, Victoria 3004, Australia 3The Womens Health Program, Department of Medicine, Monash University Medical School, Alfred Hospital, 89 Commercial Road, Prahran, Victoria 3181, Australia Corresponding author: Flavia M Cicuttini, Flavia.cicuttini@.au Received: 14 Apr 2009 Revisions requested: 8 Jun 2009 Revisions received: 14 Oct 2009 Accepted: 4 Dec 2009 Published: 4 Dec 2009 Arthritis Research Therapy 2009, 11:R181 (doi:10.1186/ar2873) This article is online at: /content/11/6/R181 ? 2009 Davies-Tuck et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Given the emerging evidence that osteoarthritis (OA) may have a vascular basis, the aim of this study was to determine whether serum lipids were associated with change in knee cartilage, presence of bone marrow lesions (BMLs) at baseline and the development of new BMLs over a 2-year period in a population of pain-free women in mid-life. confidence interval [CI] 1.01, 3.36; P = 0.048) and triglycerides (OR 8.4, 95% CI 1.63, 43.43; P = 0.01), but not high-density lipoprotein (HDL) (P = 0.93), low-density lipoprotein (LDL) (P = 0.20) or total cholesterol/