Total Ginsenosides of Radix Ginseng Modulates Tricarboxylic Acid Cycle Protein Expression to Enhance Cardiac Energy Metabolism in Ischemic Rat Heart Tissues 英文参考文献.docVIP

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Total Ginsenosides of Radix Ginseng Modulates Tricarboxylic Acid Cycle Protein Expression to Enhance Cardiac Energy Metabolism in Ischemic Rat Heart Tissues 英文参考文献.doc

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Total Ginsenosides of Radix Ginseng Modulates Tricarboxylic Acid Cycle Protein Expression to Enhance Cardiac Energy Metabolism in Ischemic Rat Heart Tissues 英文参考文献

Molecules 2012, 17, 12746-12757; doi:10.3390/molecules171112746 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Total Ginsenosides of Radix Ginseng Modulates Tricarboxylic Acid Cycle Protein Expression to Enhance Cardiac Energy Metabolism in Ischemic Rat Heart Tissues Jing-Rong Wang 1,2, Hua Zhou 1,2, Xiao-Qin Yi 2, Zhi-Hong Jiang 1,2 and Liang Liu 1,2, * 1 State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, China; E-Mails: jrwang@.mo (J.-R.W.); hzhou@.mo (H.Z.); zhjiang@.mo (Z.-H.J.) School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China; E-Mail: xqyi@.hk 2 * Author to whom correspondence should be addressed; E-Mail: lliu@.mo; Tel.: +853-8897-2799; Fax: +853-2882-7222. Received: 18 September 2012; in revised form: 8 October 2012 / Accepted: 24 October 2012 / Published: 29 October 2012 Abstracts: To elucidate the underlying mechanism of cardio-protective activity of the total ginsenosides (TGS) of Radix Ginseng, proteomic analysis using two-dimensional gel electrophoresis (2-DE) and MALDI-TOF-TOF-MS techniques was employed for identifying the underlying targets of TGS on improvement of the energy metabolism of isolated rat heart tissues perfused in Langendorff system under ischemia-reperfusion injury conditions. The image analysis results revealed 11 differentially expressed proteins in the TGS-treated heart tissues; these proteins, including LDHB and ODP-2, were found to be closely related to the function of tricarboxylic acid (TCA) cycle that plays pivotal roles in cardiac energy metabolism. It is thus concluded that improvement of cardiac energy metabolism via activating proteins in TCA cycle could be the major action pathway and targets of TGS activity against rat heart tissue injury. Keywords: total ginsenosides; proteomics; cardio-