Trinor-cycloartane Glycosides from the Rhizomes of Cimicifuga foetida 英文参考文献.docVIP

Molecules 2009, 14, 1578-1584; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Trinor-cycloartane Glycosides from the Rhizomes of Cimicifuga foetida Lu Lu 1,2, Jianchao Chen 1, Yin Nian 1,2, Yun Sun 1,2 and Minghua Qiu 1,* 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming, 650204, P. R. China 2 Graduate School of Chinese Academy of Sciences, Beijing 100039, P. R. China * Author to whom correspondence should be addressed; E-mail: mhchiu@; Tel.: +86-871-7223327; Fax: +86-871-5223255. Received: 16 March 2009; in revised form: 2 April 2009 / Accepted: 7 April 2009 / Published: 17 April 2009 Abstract: Three new trinor-cycloartane glycosides, 15α-hydroxy-16-dehydroxy-16(24)- en-foetidinol-3-O-β-D-xylopyranoside (1), 28-hydroxy-foetidinol-3-O-β-D-xylopyranoside (2) and foetidinol-3-O-β-D-xylopyranosyl-(1”→3’)-β-D-xylopyranoside (3) together with the known compound foetidinol-3-O-β-D-xylopyranoside (4) were isolated from the n- BuOH fraction of the roots of Cimicifuga foetida. Their structures were elucidated on the basis of spectroscopic and chemical reaction data. Keywords: Cimicifuga foetida; Triterpenoids; Trinor-cycloartane; Glycosides. 1. Introduction The Traditional Chinese Medicine Rhizoma Cimicifugea is used to treat toothache, mouth ulcers, sore throats and to help erupt measles [1]. The Chinese Pharmacopoeia describes three Cimicifuga species (C. foetida, C. dahurica and C. heracleifolia) as the crude drug source [1], among which C. foetida is found widely spread throughout northwest Yunnan Province [2]. Ever since three trinor-cycloartanes were found in C. foetida by Asian research groups between 1994-96 [3-7], no additional compounds with such structure have been reported, as far as we know. While we were carrying out a phytochemical investigation on