Type I interferon in organ-targeted autoimmune and inflammatory diseases 英文参考文献.docVIP

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Type I interferon in organ-targeted autoimmune and inflammatory diseases 英文参考文献.doc

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Type I interferon in organ-targeted autoimmune and inflammatory diseases 英文参考文献

Crow Arthritis Research Therapy 2010, 12(Suppl 1):S5 /content/12/S1/S5 RE VIE W Type I interferon in organ-targeted autoimmune and in? ammatory diseases Mary K Crow* functional interferon activity in lupus patient sera have Abstract been con? rmed and extended using current technologies A signi?cant role for IFNα in the pathogenesis of systemic lupus erythematosus is well supported, and clinical trials of anti-IFNα monoclonal antibodies are in progress in this disease. In other autoimmune diseases characterized by substantial in?ammation and tissue destruction, the role of type I interferons is less clear. Gene expression analysis of peripheral blood cells from patients with rheumatoid arthritis and multiple sclerosis demonstrate an interferon signature similar to but less intense than that seen in patients with lupus. In both of those diseases, presence of the interferon signature has been associated with more signi?cant clinical manifestations. At the same time, evidence supports an anti-in?ammatory and bene?cial role of IFNβ locally in the joints of patients with rheumatoid arthritis and in murine arthritis models, and many patients with multiple sclerosis show a clinical response to recombinant IFNβ. As can also be proposed for type I diabetes mellitus, type I interferon appears to contribute to the development of autoimmunity and disease progression in multiple autoimmune diseases, while maintaining some capacity to control established disease – particularly at local sites of in?ammation. Recent studies in both rheumatoid arthritis and multiple sclerosis suggest that quanti?cation of type I interferon activity or target gene expression might be informative in predicting responses to distinct classes of therapeutic agents. that permit detection of the broad gene expression program induced by type I interferons [5-8]. Expression of an interferon signature – re? ecting expression of often more than 100 type I interferon-inducible genes