白花蛇舌草抑制Lewis肺癌小鼠自发转移的实验研究.pdfVIP

2012 年9 月 第18 卷第9 期 守1. ÎÐ 毒技 Vo1.18 No.9 Guiding Joumal of Traditional Chinese Medicine and Phannacy Septemher.2012 白花蛇舌草抑制Lewis肺癌小鼠自发转移的 实验研究* 李洁1 ，李玉基2 ，李博1 (1.山东中医药大学，山东 济南 250355 ;2. 山东省药晶不良反应监测中心，山东 济南 25∞13 ) [摘要] 目的:观察白花蛇舌苹对Lewis肺癌小鼠白发转移的影响。方法:在C57BLJ、鼠右侧腋下皮下注射接种肺癌Lewis 瘤细胞悬液，复制自发转移模型，观察小鼠体重变化、实体瘤生长情况、肺转移瘤生长情况、免疫器官指数等指标变化。结果: 白花蛇舌苹作用组的小鼠，小鼠生活质量得到明显改善，免疫器官指数、抑瘤率明显增加，肺部转移结节数较空白纽明显减 少。结论:白花纶舌草可抑制Lewis肺癌小鼠自发转移。 [关键词] 白花蛇舌萃;Le叨s肺癌;抗肿瘤;白发转移 [申图分类号] R285.5 [文献标识码] A [文章编号] 1672-951X( 2012 )09-∞78-02 Experimental Research 00 Inhabita咀00 EtTect of Hedyoüs DitTusa Willd 00 Lewis Lung Canser Spontaneous Metastasis io Mouse l U Jie , U Yujr, U BOI (1 .Shandong University of TCM, Jin皿 250355 China; 2.Center for Adverse Drug Reaction Monitoring of Shandong, Jinan 251∞13 China) [Abstract] Objective: To observe the efIect of Hedyotis difIusa on inhibiting Lewis lung spontaneous metastasis in mouse. Methods: To establish 由e spontaneous metastasis model 叨th subcutaneous injection Lewis lung cancer tumor cell suspension into the C57BL mouse 由rough right axiIlaries and observe the changes of mouses wei酬， ω，lid tumor growth , lung metastasis , and immune organ index. Results: For the mice in Hedyotis difIusa role groups , the quality of mice life ohviously improved; the index of immune organs and the tumor inhihition rate were increased si伊ificantly， pulmonary metastasis nodules was sig- nificantlY reduced compared with the blank group. Conclusion: Hedyotis d证usa has an inhihitor