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- 2017-05-15 发布于上海
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A network module-based method for identifying cancer prognostic signatures
WuandSteinGenomeBiology2012,13:R112
/2012/13/12/R112
METHOD
OpenAccess
Anetworkmodule-basedmethodforidentifying
cancerprognosticsignatures
GuanmingWu1*andLincolnStein1,2
Abstract
Discoveringrobustprognosticgenesignaturesasbiomarkersusinggenomicsdatacanbechallenging.Wehave
developedasimplebutefficientmethodfordiscoveringprognosticbiomarkersincancergeneexpressiondata
setsusingmodulesderivedfromahighlyreliablegenefunctionalinteractionnetwork.Whenappliedtobreast
cancer,wediscoveranovel31-genesignatureassociatedwithpatientsurvival.Thesignaturereplicatesacross5
independentgeneexpressionstudies,andou
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