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A new category of autoinflammatory disease associated with NOD2 gene mutations
Yaoetal.ArthritisResearchTherapy2011,13:R148
/content/13/5/R148
RESEARCH ARTICLE
OpenAccess
Anewcategoryofautoinflammatorydisease
associatedwithNOD2genemutations
QingpingYao1*,LanZhou2,PhilipCusumano3,NilanjanaBose1,MelissaPiliang4,BijalJayakar1,Le-ChuSu5and
BoShen5
Abstract
Introduction:Autoinflammatorydiseasesarecharacterizedbyseeminglyunprovokedepisodesofinflammation,
withouthightitersofautoantibodiesorantigen-specificTcells,andderivefromgeneticvariantsoftheinnate
immunesystem.Thisstudycharacterizedacohortofpatientswithsimilarphenotypesandnucleotide
oligomerizationdomain2(NOD2)genemutati
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