原创力文档A new fetal RHD genotyping test Costs and benefits of mass testing to target antenatal anti-D prophylaxis in England and Wales.docVIP
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A new fetal RHD genotyping test Costs and benefits of mass testing to target antenatal anti-D prophylaxis in England and Wales
Szczepuraetal.BMCPregnancyandChildbirth2011,11:5
/1471-2393/11/5
RESEARCH ARTICLE
OpenAccess
AnewfetalRHDgenotypingtest:Costsand
benefitsofmasstestingtotargetantenatal
anti-DprophylaxisinEnglandandWales
AlaSzczepura*,LeezaOsipenko,KarolineFreeman
Abstract
Background:Postnatalandantenatalanti-Dprophylaxishavedramaticallyreducedmaternalsensitisationsand
casesofrhesusdiseaseinbabiesborntowomenwithRhDnegativebloodgroup.Recentscientificadvancesmean
thatnon-invasiveprenataldiagnosis(NIPD),basedonthepresenceofcell-freefetalDNAinmaternalplasma,could
beusedtotargetprophylaxison“atrisk”pregnancieswhe
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