A New Look at the Most Successful Prodrugs for Active Vitamin D (D Hormone) Alfacalcidol and Doxercalciferol.docVIP

Molecules 2009, 14, 3869-3880; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review A New Look at the Most Successful Prodrugs for Active Vitamin D (D Hormone): Alfacalcidol and Doxercalciferol Noboru Kubodera Chugai Pharmaceutical Co., Ltd., 2-1-1, Nihonbashi-Muromachi, Chuo-ku, Tokyo 103-8324, Japan; E-Mail: kuboderanbr@chugai-pharm.co.jp; Tel.: +81 3 3273 1010; Fax: +81 3 3281 0191 Received: 10 September 2009; in revised form: 28 September 2009 / Accepted: 28 September 2009 / Published: 29 September 2009 Abstract: Alfacalcidol (1?-hydroxyvitamin