A new tool for detection of type I interferon activation in systemic lupus erythematosus.docVIP

Kirou and Kalliolias Arthritis Research Therapy 2010,12:138 /content/12/4/138 EDITORIAL A new tool for detection of type I interferon activation in systemic lupus erythematosus Kyriakos A Kirou* and George D Kalliolias See related research by Li et al., /content/12/3/R90 on sialoadhesin (Siglec-1 or CD169), although this assay Abstract required indirect immuno ? uores cence staining [2]. Both these molecules appear promising as biomarkers of IFN-I activation in SLE. The IFN-I pathway is activated in systemic lupus erythematosus (SLE) and appears to be important in the pathogenesis of th