A new weapon against an old target.docVIP

Fiehn Arthritis Research Therapy 2011,13:122 /content/13/4/122 EDITORIAL A new weapon against an old target Christoph Fiehn* See related research by Lu et al., /content/13/2/R56 RA patients it has been shown that FR-β is selectively Abstract expressed on activated monocytes and synovial macro- phages and that MTX can enter the cell through receptor- High expression of folate receptors is characteristic for the e?ector cell population of synovial macrophages in synovial in?ammation. A new drug conjugate, EC0746, targets the folate inhibitor aminopterin to folate receptors. In